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KMID : 0614620110580010047
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Korean Journal of Gastroenterology
2011 Volume.58 No. 1 p.47 ~ p.52
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Interstitial Pneumonitis in a Patient with Chronic Hepatitis C and Chronic Renal Failure on Interferon Therapy
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Kang Eun-Jung
Kim Dong-Kyun
Jeon Seong-Ran
Choi Hyun-Sook
Jung Seung-Won
Jang Jae-Young
Lee Joon-Seong
Uh Soo-Taek
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Abstract
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After 4-months of alpha interferon (IFN-alpha), a 64-year old woman with chronic hepatitis C developed a cough and dyspnea and showed diffuse infiltrative opacities on her chest X-ray. Her symptoms persisted after stopping the IFN-alpha therapy. Pulmonary function testing revealed a reduced forced vital capacity. High-resolution computed tomography of the lung showed peripheral and peribronchovascular ground glass attenuation and consolidation associated with reticulation. Bronchoalveolar lavage was performed for further evaluation and showed a lymphocyte level of 8.2%, an uncommon finding in IFN-alpha-induced interstitial pneumonitis. We performed a lung biopsy to diagnose her disease and it suggested interstitial pneumonitis. This was considered to be due to the immunomodulatory effects of INF-alpha. Although rare, any sign of significant pulmonary involvement should be evaluated.
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KEYWORD
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Chronic hepatitis C, Interferon, , Chronic renal failure, Interstitial pneumonitis
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